Coles will undergo an MRI on the same knee that was recovering from off-season PCL surgery. He will be eligible to apply for a medical hardship waiver which, if granted, will allow him to return for a fifth season similar to fellow receiver Dyrell Roberts.
The Hokies had several other receivers step up in Coles' absence.
Marcus Davis and Corey Fuller each had 82 yards receiving and redshirt-freshman Demitri Knowles had his first career catch on a beautiful 42-yard touchdown pass from Logan Thomas.
Tech returns to action Saturday in Blacksburg against Austin Peay at 1:30 p.m. on ESPN3.